Nyssa School District includes the small, rural town of Nyssa in eastern Oregon as well as the surrounding community. Nyssa lies adjacent to the Snake River which, at the eastern city limits, forms the boundary between Oregon and Idaho. The town of Nyssa is situated approximately eleven miles south of Interstate 84 and the city of Ontario.

Nyssa schools serve an agricultural community. Located at the western end of the Treasure Valley, Nyssa exists because of the huge irrigation projects constructed during the Depression. Reservoirs built in the surrounding mountains and hills send water through a massive canal system to the valley, supplying area farms with surface irrigation. Major Nyssa area crops are sugar beets, potatoes, corn, and onions. Until recently, Amalgamated Sugar operated a large sugar beet processing factory located in the town of Nyssa. Extensive onion and potato storage and sorting sheds continue to be found throughout the community.